Publications by authors named "L Krasny"
In mycobacteria, σ is the primary sigma factor. This essential protein binds to RNA polymerase (RNAP) and mediates transcription initiation of housekeeping genes. Our knowledge about this factor in mycobacteria is limited.
View Article and Find Full Text PDFMycobacterial HelD is a transcription factor that recycles stalled RNAP by dissociating it from nucleic acids and, if present, from the antibiotic rifampicin. The rescued RNAP, however, must disengage from HelD to participate in subsequent rounds of transcription. The mechanism of release is unknown.
View Article and Find Full Text PDFIn this study, we present a high-resolution dataset and bioinformatic analysis of the proteome of Bacillus subtilis 168 trp+ (BSB1) during germination and spore outgrowth. Samples were collected at 14 different time points (ranging from 0 to 130 min) in three biological replicates after spore inoculation into germination medium. A total of 2191 proteins were identified and categorized based on their expression kinetics.
View Article and Find Full Text PDFArticle Synopsis
- The SorC family of proteins helps control how bacteria use sugar and communicate with each other.
- Scientists studied two specific proteins, DeoR and CggR, from a type of bacteria called Bacillus subtilis using advanced techniques.
- They discovered how these proteins interact with DNA and learned how two special molecules help regulate a specific gene related to sugar metabolism.
Purpose: The landscape of extracellular matrix (ECM) alterations in soft tissue sarcomas (STS) remains poorly characterized. We aimed to investigate the tumor ECM and adhesion signaling networks present in STS and their clinical implications.
Experimental Design: Proteomic and clinical data from 321 patients across 11 histological subtypes were analyzed to define ECM and integrin adhesion networks.