Publications by authors named "L Kozlovskaya"
The article is devoted to the problems of implementation of the WHO Global Polio Eradication Initiative. The influence of the features of poliovirus infection and poliovirus vaccines on the course of the program, its successes and difficulties is considered, the issue of possibility of eradication this infection is discussed.
View Article and Find Full Text PDFPrevalence and Clinical Impact of Viral and Bacterial Coinfections in Hospitalized Children and Adolescents Aged under 18 Years with COVID-19 during the Omicron Wave in Russia.
Viruses
July 2024
Article Synopsis
- * A study in Russia examined 574 hospitalized children under 18 with COVID-19 from January 2022 to March 2023, finding about one-third had coinfections, predominantly adenovirus and bacterial infections.
- * Results indicated that while viral coinfections led to higher fevers and bronchitis, bacterial coinfections resulted in longer illnesses and increased pneumonia, suggesting that seasonal viruses may have been more harmful to children during the Omicron wave than SARS-CoV-2 alone.
The widespread use of the oral poliovaccine from Sabin strains (tOPV) radically reduced poliomyelitis incidence worldwide. However, OPV became a source of neurovirulent vaccine-derived polioviruses (VDPVs). Currently, circulating type 2 VDPVs (cVDPV2) are the leading cause of poliomyelitis.
View Article and Find Full Text PDFArticle Synopsis
- X-ray structures of coronavirus drug targets were rapidly acquired during the early COVID-19 pandemic, especially focusing on the main protease (Mpro) of SARS-CoV-2, which is crucial for developing direct antiviral drugs.
- A systematic, semi-automated method was developed to select the best ensemble of Mpro structures for virtual screening of potential inhibitors, as the selection process was complex.
- This method was validated against existing approaches and led to the discovery of new thienopyrimidinone derivatives that effectively inhibit the Mpro enzyme.
Based on the success of the Sabin2-based vaccine, a next-generation nOPV2 poliovirus vaccine has been developed. For epidemic monitoring and conducting epidemiological investigations, it is necessary to have a diagnostic assay with the ability to differentiate this variant from others. Here we describe such a real-time RT-PCR assay.
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