Publications by authors named "L Korngut"
Introduction/aims: Fluctuating symptoms and fatigue are common issues in myasthenia gravis (MG), but it is unclear if these symptoms are related to physical activity or sleep patterns. This study sought to determine the day-to-day relationship between patient-reported symptoms and physical activity and sleep over 12 weeks.
Methods: Sixteen participants with generalized MG wore a wrist-mounted accelerometer continuously for the study duration and reported their symptoms and fatigue each evening.
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder of motor neurons in the brain and spinal cord. Accumulation of misfolded proteins is central to the pathogenesis of ALS and the glymphatic system is emerging as a potential therapeutic target to reduce proteinopathy. Using diffusion tensor imaging analysis along the perivascular spaces (DTI-ALPS) to assess glymphatic function, we performed a longitudinal analysis of glymphatic function in ALS and compared it to a disorder in the motor neuron disease spectrum, primary lateral sclerosis (PLS).
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- * A retrospective analysis of 179 gMG patients from the University of Calgary found that the likelihood of starting treatment and the time from diagnosis to treatment initiation did not differ between sexes when accounting for various factors.
- * The findings suggest that the differences in quality of life seen in females with gMG are not related to treatment initiation, indicating that further research should focus on exploring physician and patient preferences in treatment strategies.
Objective: The corticospinal tract (CST) reveals progressive microstructural alterations in ALS measurable by DTI. The aim of this study was to evaluate fractional anisotropy (FA) along the CST as a longitudinal marker of disease progression in ALS.
Methods: The study cohort consisted of 114 patients with ALS and 110 healthy controls from the second prospective, longitudinal, multicentre study of the Canadian ALS Neuroimaging Consortium (CALSNIC-2).
Article Synopsis
- This study explored how brain degeneration correlates with the progression of amyotrophic lateral sclerosis (ALS) by analyzing brain scans of 149 ALS patients and 144 healthy controls.
- Researchers used a texture analysis method on MRI scans to identify "autocorrelation," a biomarker indicating brain degeneration, focusing on different stages of the disease.
- Results showed that brain changes varied significantly depending on the criteria used for patient classification, suggesting that standard clinical trial measures may not fully capture the extent of brain degeneration in ALS patients.