Publications by L Koneva

Publications by authors named "L Koneva"

Nat Cardiovasc Res

August 2023

Nat Cardiovasc Res

June 2023

The immune system plays a crucial role in cardiovascular health, particularly in relation to inflammation and its impact on heart disease.
Atherosclerosis is characterized by lipid-driven inflammation, where macrophages are key players; however, recent research indicates that there are different macrophage states associated with lipids and inflammation.
This study identifies a specific type of macrophage linked to cerebrovascular events and suggests that targeting these inflammatory lipid-associated macrophages could be a new treatment approach for cardiovascular disease.

Nat Commun

January 2023

IFNγ is an immune mediator involved in both promoting and inhibiting tumor responses, particularly affecting CD8 T cells' ability to combat tumors.
High expression of the IFNγ receptor β chain (IFNγR2) in CD8 T cells is linked to poor responses to cancer treatments in melanoma patients, indicating that sensitivity to IFNγ influences anti-tumor effectiveness.
The study suggests that chronic IFNγ leads to the depletion of stem-like T cells and reduces their diversity and proliferation, creating a feedback loop that limits anti-tumor immunity, highlighting a potential target for improving T cell therapies.

Nat Cardiovasc Res

August 2023

- The text is a correction relating to a previously published article.
- It specifically addresses issues found in the original article identified by the DOI 10.1038/s44161-023-00295-x.
- This correction is essential for ensuring the accuracy and integrity of the published research.

Sci Transl Med

December 2022

* Researchers confirmed these genetic risk variants in the U.K. Biobank and studied articular cartilage from patients to understand their biological impact, finding a link between inflammatory genes and cartilage injury known as mechanoflammation.
* The study showed that using talarozole, a drug that blocks retinoic acid metabolism, can reduce inflammation and cartilage damage, indicating that it might be a promising treatment option for OA.