Evaluation of humoral and cell-mediated inducible immunity to Haemophilus ducreyi in an animal model of chancroid.

To study the mechanisms of inducible immunity to Haemophilus ducreyi infection in the temperature-dependent rabbit model of chancroid, we conducted passive immunization experiments and characterized the inflammatory infiltrate of chancroidal lesions. Polyclonal immunoglobulin G was purified from immune sera raised against H. ducreyi 35000 whole-cell lysate or a pilus preparation and from naive control rabbits.

Chromogranin A-like immunoreactivity in the human brain: distribution in bulbar medulla and cerebral cortex.

Chromogranin A is a glycoprotein stored in secretory granules of a variety of neuroendocrine cells. Among other functions, chromogranin A is a calcium-binding protein, and a precursor of modulatory peptides. Although known to be expressed in mammalian CNS neurons, it was previously believed that antibodies directed against human chromogranin A did not label neurons.