Publications by authors named "L Knopfova"
Fas ligand (FasL, CD178) belongs to classical apoptotic molecules, however, recent evidence expands the spectrum of FasL functions into non-apoptotic processes which also applies for the bone. Tgfb subfamily members (Tgfb1, Tgfb2, Tgfb3) represent major components in osteogenic pathways and extracellular matrix. Their possible association with FasL has not yet been investigated but can be postulated.
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- - Caspase-9 is known for triggering cell death in the intrinsic apoptotic pathway, but recent research has shown that it also plays roles in cell growth, development, and maintaining cellular health beyond apoptosis.
- - A study using advanced proteomics compared protein levels in normal and caspase-9 knockout mouse osteoblasts (MC3T3-E1), identifying a significant number of proteins that were altered—283 were upregulated and 141 were downregulated upon caspase-9 knockout.
- - The changes in protein expression were linked to processes like cell migration and DNA repair, suggesting that caspase-9 influences the movement of osteoblasts, which may have implications for bone healing and remodeling. *
As the dentition forms and becomes functional, the alveolar bone is remodelled. Metalloproteinases are known to contribute to this process, but new regulators are emerging and their contextualization is challenging. This applies to Myb, a transcription factor recently reported to be involved in bone development and regeneration.
View Article and Find Full Text PDFThe transcription factor c-Myb is overexpressed in many different types of solid tumors, including colorectal cancer. However, its exact role in tumorigenesis is unclear. In this study, we show that tumor-intrinsic c-Myb expression in mouse models of colon cancer and melanoma suppresses tumor growth.
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