Publications by authors named "L Kinnunen"
Wellcome Open Res
October 2023
Article Synopsis
- Genome-wide association studies have found numerous genetic loci linked to glycemic traits, but connecting these loci to specific genes and biological pathways remains a challenge.
- Researchers conducted meta-analyses of exome-array studies across four glycemic traits, analyzing data from over 144,000 participants, which led to the identification of coding variant associations in more than 60 genes.
- The study revealed significant pathways related to insulin secretion, zinc transport, and fatty acid metabolism, enhancing understanding of glycemic regulation and making data available for further research.
Article Synopsis
- * A large study involving over 150,000 individuals found that genetic effects on fasting insulin vary by sex, specifically at the IRS1 and ZNF12 gene locations, with women showing higher RNA expression levels for ZNF12.
- * The findings highlight that fasting insulin in women correlates more strongly with certain conditions like waist-to-hip ratio and anorexia nervosa, indicating that metabolic health differences between sexes may provide insight into their respective genetic influences.
