Brief Note: Response to Benatar.

In his response to my article entitled 'The Harm of Male-on-Female Rape: A Response to David Benatar', Benatar argues that I take his claims out of context, misrepresent them, and set up a straw man, which means, he claims, that I fail to respond to anything he has actually said. In this brief note, I respond to these allegations.

The harm of male-on-female rape: a response to David Benatar.

This article attacks David Benatar's claim made in his 2012 book, The Second Sexism: Discrimination Against Men and Boys, that when an individual is the victim of violence it does not matter whether his or her perpetrator is of the same or a different sex. By exploring two related yet distinct phenomena, well documented in the empirical psychological literature, that I call "shattering" and "fragmentation," I argue that when a woman is raped, it does matter that her rapist is male, given that her situation as a woman under patriarchy is partly constitutive of the harm that she suffers.

Luminescent 'On-Off' CdSe/ZnS quantum dot chemodosimeter for hydroxide based on photoinduced electron transfer from a carboxylate moiety.

A CdSe-ZnS quantum dot (QD) has been surface functionalised by a place exchange reaction with p-mercaptomethyl benzoate synthesized by a three-step procedure. The resulting lumophore-spacer-receptor QD-conjugate was characterized by IR, UV-visible and fluorescence spectroscopy. The emission profile of the QD reveals a narrow emission peak centred at 542 nm.

Design, synthesis and biological evaluation of 6-pyridylmethylaminopurines as CDK inhibitors.

The cyclin-dependent kinase (CDK) inhibitor seliciclib (1, CYC202) is in phase II clinical development for the treatment of cancer. Here we describe the synthesis of novel purines with greater solubility, lower metabolic clearance, and enhanced potency versus CDKs. These compounds exhibit novel selectivity profiles versus CDK isoforms.

Guidelines for the welfare and use of animals in cancer research.

Animal experiments remain essential to understand the fundamental mechanisms underpinning malignancy and to discover improved methods to prevent, diagnose and treat cancer. Excellent standards of animal care are fully consistent with the conduct of high quality cancer research. Here we provide updated guidelines on the welfare and use of animals in cancer research.