Publications by authors named "L Karsai"
Small extracellular vesicles (sEVs) contain microRNAs (miRNAs) which have potential to act as disease-specific biomarkers. The current study uses an established method to maintain human thyroid tissue ex vivo on a tissue-on-chip device, allowing the collection, isolation and interrogation of the sEVs released directly from thyroid tissue. sEVs were analysed for differences in miRNA levels released from benign thyroid tissue, Graves' disease tissue and papillary thyroid cancer (PTC), using miRNA sequencing and quantitative reverse transcriptase polymerase chain reaction (qRT-PCR) to identify potential biomarkers of disease.
View Article and Find Full Text PDFA woman in her 20s presented with a non-tender swelling of the right submandibular gland. Ultrasound was suggestive of pleomorphic adenoma. The histology result of the excised tumour later confirmed a diagnosis of nodular fasciitis which is extremely rare in the submandibular gland.
View Article and Find Full Text PDFArticle Synopsis
- Patient-specific approaches to cancer treatment are essential due to the varying efficacy of current therapies, particularly in thyroid cancer where about 10% of patients do not respond to standard radioiodine treatment.
- Researchers conducted a study using human thyroid tissue samples to assess the viability and differentiation of malignant and benign cells in a controlled culture environment.
- Results showed that while initial cellular damage occurred, overall tissue architecture was maintained and there was a significant increase in apoptosis when treated with directed compounds, highlighting the potential for improved therapeutic strategies.