Publications by authors named "L Karl"
Article Synopsis
- Fun30 is a nucleosome remodeler involved in DNA repair and gene silencing, but its mechanisms are not well understood.
- A conserved domain called SAM-key was identified, which is crucial for Fun30’s function; deleting it results in defects similar to a mutant form of the protein.
- Structural modeling and experiments show that the SAM-key helix interacts with other protein regions to regulate ATPase activity, essential for nucleosome remodeling.
Introduction: Strong and efficient institutions are vital to the development of well-functioning governments and strong societies. The term "institution building" encompasses the creation, support, development, and strengthening of organizations and institutions. Still, there is little aggregated evidence on "institution building" considering a wider system-thinking approach, best practices, or development cooperation specifically in the field of public health.
View Article and Find Full Text PDFThe origin recognition complex (ORC) is essential for initiation of eukaryotic chromosome replication as it loads the replicative helicase-the minichromosome maintenance (MCM) complex-at replication origins. Replication origins display a stereotypic nucleosome organization with nucleosome depletion at ORC-binding sites and flanking arrays of regularly spaced nucleosomes. However, how this nucleosome organization is established and whether this organization is required for replication remain unknown.
View Article and Find Full Text PDFBackground: Exercise is a non-pharmacological intervention that may benefit elderly patients with depression, but the effects of an exercise intervention in geriatric psychiatry outpatients have yet to be tested.
Method: Outpatients in a geriatric psychiatry clinic participated in a structured exercise intervention of 50 minutes, twice-weekly, over twelve weeks. Depressive symptoms were assessed at baseline and post-intervention using the Patient Health Questionnaire-9 (PHQ-9).
DNA double strand breaks (DSBs) are repaired in eukaryotes by one of several cellular mechanisms. The decision-making process controlling DSB repair takes place at the step of DNA end resection, the nucleolytic processing of DNA ends, which generates single-stranded DNA overhangs. Dependent on the length of the overhang, a corresponding DSB repair mechanism is engaged.
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