Publications by authors named "L Kager"

Helmut Gadner, a world-famous pediatric hematologist-oncologist, dedicated his professional life to researching pediatric cancer and advancing care for affected children, adolescents, and their families. Starting his career in the team of Hansjörg Riehm, the father of the ever-most successful BFM (abbreviation of the city names of the founding institutions, Berlin-Frankfurt-Münster) treatment concept of pediatric leukemia, the young Dr. Gadner became a passionate soldier in the fight against pediatric cancer.

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Background: Osteosarcoma may arise as a secondary malignancy following rhabdomyosarcoma (RMS). We utilized the Cooperative Osteosarcoma Study Group (COSS) database to better understand this association.

Patients And Methods: The COSS database (1980-05/2023) was searched for patients whose osteosarcoma was preceded by RMS.

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Purpose: Prognostic factors have been well described for osteosarcoma, but analyses evaluating the further course of long-term survivors are lacking. We used the large database of the Cooperative Osteosarcoma Study Group (COSS) to perform such an analysis.

Patients And Methods: The COSS database 1980-04/2019 was searched for 5-year survivors of primary high-grade central osteosarcoma of the extremities or trunk.

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Article Synopsis
  • Osteosarcoma and Ewing sarcoma are challenging bone tumors primarily affecting younger individuals, with low survival rates even after various treatment approaches.
  • Current research on targeted therapies and immunotherapies has been ineffective, highlighting the need for a deeper understanding of the tumor biology and the immune microenvironment.
  • A new Europe-wide framework for systematic sampling and analysis of patient samples has been proposed, supported by international consortia aiming to set guidelines that will enhance research collaboration and ultimately improve treatment outcomes.
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