Publications by authors named "L KIRSCHNER"
Staining patterns of aldosterone synthase in patients undergoing surgery for primary aldosteronism: Proposal for system of categorization and investigation of clinical and biochemical correlation.
Surgery
January 2025
Article Synopsis
- The study investigates the association between CYP11B2 staining patterns in adrenal tissues and patient outcomes after adrenal surgery in individuals with unilateral primary aldosteronism.
- A total of 43 patients were reviewed, identifying five distinct CYP11B2 staining patterns, with most cases showing a single adenoma, but also instances of additional staining in nonadenomatous tissues.
- While the majority of patients achieved biochemical cures, the study found no correlation between CYP11B2 staining patterns and clinical outcomes or demographic factors, highlighting the need for further research to understand these relationships.
Background: Intraoperative end-tidal carbon dioxide concentrations (EtCO) values are associated with recurrence-free survival after colorectal cancer surgery. However, it is unknown if similar effects can be observed after other surgical procedures. There is now evidence available for target EtCO and its relation to surgical outcomes following pancreatic cancer surgery.
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- Hereditary mutant pheochromocytomas (PC) and paragangliomas (PG) are rare tumors that tend to metastasize unpredictably, prompting a study to better understand their genomic characteristics.
- A multi-omic analysis of 94 tumors from 79 patients revealed distinct molecular profiles based on whether the tumors originated from sympathetic or parasympathetic cells, with specific alterations linked to metastatic behavior.
- The study also identified high mutation loads, unusual genomic features, and mechanisms of resistance to DNA alkylating chemotherapies, enhancing the comprehension of these complex neuroendocrine tumors and their treatment responses.
Study Objective: Higher levels of carbon dioxide (CO) increase the invasive abilities of colon cancer cells in vitro. Studies assessing target values for end-tidal CO concentrations (EtCO) to improve surgical outcome after colorectal cancer surgery are lacking. Therefore, we evaluated whether intraoperative EtCO was associated with differences in recurrence-free survival after elective colorectal cancer (CRC) surgery.
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