Publications by authors named "L K Velayudhan"
Background: The novel South London and Maudsley Brain Health Clinic (SLaM BHC) leverages advances in remote consultations and biomarkers to provide a timely, cost-efficient and accurate diagnosis in mild cognitive impairment (MCI).
Aims: To describe the organisation, patient cohort and acceptability of the remote diagnostic and interventional procedures.
Method: We describe the recruitment, consultation set-up, the clinical and biomarker programme, and the two online group interventions for cognitive wellbeing and lifestyle change.
Article Synopsis
- Cannabinoid-based medicines (CBMs) are increasingly used among older adults, but there is limited information on their adverse events (AEs).
- This study conducted a systematic review and meta-analysis of 58 randomized clinical trials involving participants aged 50 and older, examining the incidence of AEs associated with CBMs, particularly those containing delta-9-tetrahydrocannabinol (THC).
- Results indicate that THC-containing CBMs have a higher incidence of specific AEs like dry mouth and dizziness, with varying impacts based on the weekly doses of THC and cannabidiol (CBD), although serious AEs were not significantly higher compared to controls.
Neural underpinnings of Parkinson's disease psychosis remain unclear to this day with relatively few studies and reviews available. Using a systematic review approach, here, we aimed to qualitatively synthesize evidence from studies investigating Parkinson's psychosis-specific alterations in brain structure, function or chemistry using different neuroimaging modalities. PubMed, Web of Science and Embase databases were searched for functional MRI (task-based and resting state), diffusion tensor imaging, PET and single-photon emission computed tomography studies comparing Parkinson's disease psychosis patients with Parkinson's patients without psychosis.
View Article and Find Full Text PDFBackground: Cognitive deficits are associated with poor quality of life and increased risk of development of dementia in patients with Parkinson's disease (PD) psychosis. The trajectory of cognitive decline in PD psychosis remains however unclear.
Objective: We examined this using data from the Parkinson's Progression Markers Initiative study.