Publications by authors named "L K Trefzer"
[Retrospective analysis in children with vaccination granuloma].
Dermatologie (Heidelb)
January 2025
Background: Vaccine granulomas are a common (0.3-1%) adverse event (AE) of (accidentally) subcutaneously administered vaccines and specific immunotherapies containing aluminum conjugates. The clinical symptoms with persistent itching subcutaneous nodules, predominantly affect infants and young children on the lateral thigh.
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- Genetic diseases that cause skin fragility are diverse in their symptoms and genetic causes, making it crucial for healthcare professionals to differentiate them from more common conditions like infections or burns.
- The classification of these rare diseases is guided by their clinical presentation, histological characteristics, and genetic mutations, with most treatments being symptomatic rather than curative.
- Advances in genetic testing have integrated the study of these rare diseases into everyday clinical practice, emphasizing the need for collaboration among specialists to ensure proper diagnosis and care for affected children.
Biologics are approved for various dermatologic, allergic, rheumatic, and gastroenterologic inflammatory diseases, as well as for numerous malignancies. The dermatologic adverse events from treatment with biologics may resemble primary inflammatory diseases but differ in pathogenesis. In this article, we describe five different pathogenic mechanisms of dermatologic adverse events.
View Article and Find Full Text PDFCutaneous squamous cell carcinoma (cSCC) is a major complication of recessive dystrophic epidermolysis bullosa (RDEB) that has high morbidity and mortality rates and unmet therapeutic needs. The aim of this study was to evaluate the molecular pattern of cSCC and the clinical course of immunotherapy in 2 RDEB patients with multiple advanced cSCC. Clinical course and disease staging were evaluated retrospectively.
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