Hypomyelination in Weimaraner dogs.

Dogs from two separate litters of Weimaraners developed tremors by 3 weeks of age. Light and electron microscopic findings in one dog from each of the litters were compared to those of two age-matched controls. Many axons in the brain and spinal cord were either thinly myelinated or nonmyelinated in the affected dogs relative to the controls, while the peripheral nervous system was normally myelinated.

Distal renal tubular acidosis and hepatic lipidosis in a cat.

Clinical and laboratory evidence of hepatic failure was found in a chronically anorectic cat. Simultaneous blood and urine pH determinations established a diagnosis of distal renal tubular acidosis. The cat did not respond to treatment.

Ibuprofen toxicosis in a dog.

Acute renal failure, vomiting, and melena developed in a 10-month-old dog after ingestion of ten 600-mg tablets of ibuprofen. After 5 days of IV fluid therapy, clinical signs resolved and azotemia decreased. With increased availability of nonsteroidal anti-inflammatory drugs, similar complications may become more common in veterinary practice.

Amyloidosis in a dog: treatment with dimethylsulfoxide.

A dog with hypoalbuminemia, proteinuria, and renal amyloidosis was treated with dimethylsulfoxide for 2 years. During a 1-year period, serum albumin concentrations increased to within normal range. The 24-hour urinary protein excretion was 5.