[The induction of cancer of the large intestine in Macaca fascicularis monkeys with 1,2-dimethylhydrazine].

Continuous subcutaneous administration of 16 mg/kg body weight 1,2-dimethylhydrazine three times a month (total dose--1080-3696 mg) to Macaca fascicularis monkeys induced cancer invariably confined to the colon within 34-47 weeks. Biologic, clinical, histologic features and natural course of the tumor proved similar to those of its human counterpart.

[Electrophoretic mobility of the cells of non-T, non-B acute lymphoblastic leukemia].

In order to ascertain the possibility of the use of electrophoretic mobility (EPM) as one of the criterion for delicate identification of the leukemic cell, a study was made of the EPM of blast cells having an approximately equal status of differentiation. A study was also made of lymphoblasts of the most frequently occurring variant of acute lymphoblastic leukemia, namely of the non-T, non-B variant. It has been established that the given cells are marked by the similar values of the EPM, which greatly exceed the analogous characteristics of normal mature B lymphocytes, being lower as compared with the EPM of T lymphocytes.

[Dependence of the antitumor activity of nitroso alkyl urea derivatives on their chemical structure].

The antitumour activity of 10 analogs of nitroso alkyl urea was studied on 6 tumour strains. It was shown that antitumour effect depends upon the gentle structural changes of substances (changes of side chain, the position of aromatic nucleus in it, as well as the nature, quantity and position of substitutes in the nucleus). 7 compounds out of 10 analogs of nitroso alkyl urea have manifested antitumour activity.

Induction of gastric cancer in monkeys by N-methyl-N-nitro-N-nitrosoguanidine (MNNG).

N-methyl-N-nitro-N-nitrosoguanidine (MNNG) was administered to 9 Macaca fascicularis monkeys (7 males and 2 females) through a tube at a dose of 40 mg/kg body weight 3 times a month. Tumors of the pyloric part of the stomach were observed in 2 male monkeys after MNNG doses of 800 and 848 mg/kg body weight, with a latent period of tumor development of 49 and 50 weeks, respectively. Histologically, in one case the tumor was a solid carcinoma, and in the other it had a mixed structure showing alternating solid and signet ring cell carcinoma areas.

[The induction of stomach cancer in monkeys with N-methyl-N'-nitro-N-nitrosoguanidine].

Gastric tumors were detected in 2 out of 9 apes following MNNG treatment with a total dose of 800-848 mg/kg (40 mg/kg, thrice a month, 49-50 weeks, via gastric probe). The characteristics, course, symptoms and histologic patterns of the tumors proved comparable with similar neoplasms in humans.