Firearm and Motor Vehicle Pediatric Deaths-Intersections of Age, Sex, Race, and Ethnicity.

Importance: Injuries from firearms and motor vehicle crashes (MVCs) are the leading causes of death among US children and youths aged 0 to 19 years. Examining the intersections of age group, sex, race, and ethnicity is essential to focus prevention efforts.

Objective: To examine firearm and motor vehicle fatality rates by population subgroups and analyze changes over time.

Patterns and correlates of two-year changes in depressive symptoms for autistic adults.

Background: Autistic adults are at elevated risk for depression. However, longitudinal data on the trajectory of depressive symptoms and its associated factors in autistic adults are scarce.

Methods: A community sample of 315 autistic adults participated in a two-year longitudinal study from the beginning of (March 2020) to the recovery from the COVID-19 pandemic (March 2022).

Brief Report: Psychometric Properties of the Brief Problem Monitor-Parent (BPM-P) 6-18 in a Sample of Children Referred to an Autism Specialty Clinic.

Detection and monitoring of emotional and behavior problems is a critical part of clinical care for children diagnosed with autism spectrum disorder (ASD) and other neurodevelopmental disorders (NDDs), as well as a common focus of research. The Child Behavior Checklist (CBCL) is a well-established caregiver-report instrument that is used for screening and monitoring of emotional and behavior problems in individuals diagnosed with ASD and NDDs. However, it has over 100 items and can be time-consuming to complete.

No Evidence of Early Developmental Delay in Juvenile-Onset Huntington's Disease Patients.

Background: Previous studies suggest that early developmental delay is a common feature of Juvenile-Onset Huntington's disease (JOHD), with highest incidence in those with very high CAG repeats (> 80). However, all reports of developmental delay in JOHD are exclusively based on retrospective review of medical charts. Comprehensive assessment of birth history metrics may provide better insight into the question of early life development in JOHD.

BCL11A +58/+55 enhancer-editing facilitates HSPC engraftment and HbF induction in rhesus macaques conditioned with a CD45 antibody-drug conjugate.

Editing the +58 region of the BCL11A erythroid enhancer has shown promise in treating β-globin disorders. To address variations in fetal hemoglobin (HbF) response, we investigated editing both +58 and +55 enhancers. Rhesus macaques transplanted with edited hematopoietic stem/progenitor cells (HSPCs) following busulfan conditioning exhibited durable, high-level (∼90%) editing frequencies post transplantation with sustained HbF reactivation over 4 years, without hematological perturbations.