Publications by authors named "L K Norton"
Purpose: In light of evolving evidence that some patients with node-positive estrogen receptor-positive (ER+) disease may receive less benefit from chemotherapy, this study reports 12-year outcomes of the C9741 trial overall, and by the sensitivity to endocrine therapy (SET2,3) test index, a biomarker measuring endocrine transcriptional activity, to identify patients most likely to benefit from dose-dense chemotherapy.
Methods: In all, 1,973 patients were randomly assigned to dose-dense versus conventional chemotherapy. Hazard ratios (HRs) for prognosis and for predictive interaction with chemotherapy schedule were estimated from Cox models of long-term disease-free survival (DFS) and overall survival (OS).
Article Synopsis
- More children are being diagnosed with eating disorders (EDs), and there's often a delay from when parents notice early warning signs to when they seek help.
- The study analyzed various websites to pinpoint common early warning signs of EDs as observed by caregivers, resulting in the identification of 24 specific signs across six categories.
- Key signs include excessive exercise, noticeable weight loss, food obsessions, and cutting out major food groups, emphasizing the need for further research to confirm these findings and improve early detection strategies.
Regional scale diversity and distribution of soil inhabiting Tetracladium.
Environ Microbiome
December 2024
The genus Tetracladium has historically been regarded as an aquatic hyphomycete. However, sequencing of terrestrial ecosystems has shown that Tetracladium species might also be terrestrial soil and plant-inhabiting fungi. The diversity of Tetracladium species, their distribution across ecosystems, and the factors that shape community composition remain largely unknown.
View Article and Find Full Text PDFArticle Synopsis
- University students experience high levels of psychological distress, prompting the need for accessible mental health treatments, particularly through internet-delivered therapies like internet-delivered cognitive behavioural therapy (iCBT).
- This study aimed to evaluate the effectiveness and acceptability of a brief iCBT program offered by an Australian university's counseling service, assessing its impact on anxiety and depression over a five-year period with 845 students involved.
- Results showed significant reductions in symptoms of depression (27% decrease) and anxiety (37% decrease), with over 70% of participants expressing high satisfaction and more than 50% reporting significant improvement by the end of the treatment.