Publications by authors named "L K Mitre"
Introduction: Judo, a martial art created by Jigoro Kano in 1882, is a martial art promoting physical and spiritual development. Despite its "gentle way" philosophy, it poses a significant risk for cervical spine injuries, often resulting from throws and ground techniques.
Methods: This cross-sectional study analyzed cervical injuries among professional judo athletes from January to July 2024.
Efficacy and safety of anticoagulant and antiplatelet therapies in the medical management of carotid free-floating thrombus: A systematic review.
Interv Neuroradiol
December 2024
Background: The optimal treatment for carotid free-floating thrombus (CFFT) remains uncertain due to limited evidence, with no randomized clinical trials and scarce guidelines, such as ESVS 2023, favoring conservative management. Anticoagulation (ACT) and antiplatelet (APT) therapies are emerging as promising alternatives to high-risk surgical interventions. This systematic review aimed to evaluate the safety and efficacy of ACT and APT therapies for CFFT.
View Article and Find Full Text PDFCerebral Proliferative Angiopathy (CPA) is a rare brain vascular malformation, similar to Arteriovenous Malformations (AVM) but lacking of early venous drainage. Presentation and treatment outcomes were investigated, examining for morbidity, mortality and complications. A meta-analysis was conducted according to PRISMA guidelines.
View Article and Find Full Text PDFBackground: High-grade gliomas (HGG) are the most aggressive primary brain tumors with poor prognoses despite conventional treatments. Immunotherapy has emerged as a promising avenue due to its potential to elicit a targeted immune response against tumor cells.
Objective: This meta-analysis aimed to evaluate the efficacy and safety of various immunotherapeutic strategies, including immune checkpoint inhibitors (ICI), virotherapy, and dendritic cell vaccines (DCV) in treating HGG.
Article Synopsis
- The study aims to understand the immune cell composition in human atherosclerotic plaques, which differs significantly from what is observed in mouse models, often used for research.
- Single-cell RNA sequencing was employed to reveal a diverse immune cell landscape in human plaques, primarily consisting of T-cells, highlighting activation and memory formation that aren't adequately represented in mice.
- The findings suggest that traditional mouse models may not effectively translate to human atherosclerosis, particularly regarding activated T-cell responses, posing questions about their relevance in studying adaptive immune cell behavior.