Publications by authors named "L K McLoon"
Age-related macular degeneration (AMD) is a major cause of vision loss in older adults. AMD is caused by degeneration in the macula of the retina. The retina is the highest oxygen consuming tissue in our body and is prone to oxidative damage.
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- Phlebotomy-induced-anemia (PIA) in neonatal rats is examined for its effects on retinopathy of prematurity (ROP), revealing that PIA may actually decrease the severity of the condition rather than worsen it as initially hypothesized.* -
- In the study, PIA resulted in a significant decrease in avascular and neovascular areas of the retina, as well as lower levels of several pro-inflammatory cytokines at key developmental stages (P15 and P20).* -
- Findings suggest that anemia has a protective effect against pathological retinal changes in ROP, influencing gene expression and molecular pathways associated with angiogenesis and inflammation, with notable differences observed based on the sex of the subjects.*
Effects of Short-Term Treatment of Rabbit Extraocular Muscle With Ciliary Neurotrophic Factor.
Invest Ophthalmol Vis Sci
September 2024
Purpose: Little is known about the effect of ciliary neurotrophic factor (CNTF) on extraocular muscles, but microarray studies suggested CNTF might play a role in the development and/or maintenance of strabismus. The effect of short-term treatment of adult rabbit extraocular muscle with injected CNTF was examined for its ability to alter muscle characteristics.
Methods: Eight adult New Zealand white rabbits received an injection into one superior rectus muscle of 2 µg/100 µL CNTF on 3 consecutive days.
Nystagmus in the B6(CG)Tyr(c-2J)/J Albino Mouse: A Functional and RNA-Seq Analysis.
Invest Ophthalmol Vis Sci
January 2024
Purpose: Infantile nystagmus syndrome (INS) is a gaze-holding disorder characterized by conjugate, uncontrolled eye oscillations that can result in significant visual acuity loss. INS is often associated with albinism, but the mechanism is unclear. Albino mice have nystagmus; however, a pigmented mouse with a tyr mutation making it phenotypically albino, the B6(CG)-Tyr(c-2J)/J (B6 albino), had not been tested.
View Article and Find Full Text PDFPurpose: To determine the retinal transcriptomic differences underlying the oxygen-induced retinopathy phenotypes between Sprague Dawley rat pups from two commonly used commercial vendors. This will allow us to discover genes and pathways that may be related to differences in disease severity in similarly aged premature babies and suggest possible new treatment approaches.
Methods: We analyzed retinal vascular morphometry and transcriptomes from Sprague Dawley rat pups from Charles River Laboratories and Envigo (previously Harlan).