CCL2/CCR2 Signalling in Mesenchymal Stem/Progenitor Cell Recruitment and Fracture Healing in Mice.

Macrophage efferocytosis (clearance of apoptotic cells) is crucial for tissue homeostasis and wound repair, where macrophages secrete factors that promote resolution of inflammation and regenerative signalling. This study examined the role of efferocytic macrophage-associated CCL2 secretion, its influence on mesenchymal stem/progenitor cell (MSPC) chemotaxis, and in vivo cell recruitment using Ccr2 (KO) mice with disrupted CCL2 receptor signalling in two regenerative models: ossicle implants and ulnar stress fractures. Single cell RNA sequencing and PCR validation indicated that efferocytosis of various apoptotic cells at bone injury sites (osteoblasts, pre-osteoblasts, MSPC) upregulated CCL2.

Using an organizational framework to drive change in nursing education: An action plan for nurse leaders.

Background: Organizational change within nursing schools that supports growth of students, faculty, and staff from underrepresented groups occurs through purposeful strategies and commitments to building capacity for the spectra and richness of diverse perspectives.

Purpose: To evaluate framework-guided initiatives, our organization implemented to advance diversity, equity, and inclusion to achieve inclusive excellence in nursing education and leadership.

Methods: Framework-guided initiatives include a standardized diversity education model, hiring bias mitigation strategies, equitable spending, partnerships for student and faculty recruitment, and restructuring committees to include diverse perspectives.

Leverage pre-requisite courses to teach bachelor of science in nursing students about social determinants of health.

Background: Nurses have frequent opportunities to address social determinants of health (SDOH) in practice. However, many nurses graduate without completing coursework in SDOH, and there remain barriers to incorporating SDOH content into nursing curricula.

Purpose: We propose the revision of nursing pre-requisites to include substantive, introductory coursework on SDOH.

The growth and development of a novel distance accelerated bachelor of science in nursing program.

Severe nursing shortages threaten the sustainability of US health systems. Rural and underserved communities are disproportionately affected by staffing crises and associated facility closures, as well as health disparities. A major factor contributing to geographic gaps in care is the absence of nursing schools, nursing faculty, and locations for clinical rotations in many rural and underserved areas.