Publications by authors named "L K Marriott"

Article Synopsis
  • - Huntington's disease (HD) is a genetic disorder that leads to the loss of specific neurons in the brain, causing motor dysfunction, and researchers are exploring cell replacement therapies to restore neuronal function.
  • - The study focuses on creating human lateral ganglionic eminence precursors (hiLGEPs) from adult human skin cells through a process called direct reprogramming, which was evaluated for its ability to differentiate into functional neurons.
  • - Results showed that hiLGEPs could be successfully produced and transplanted into rats with HD-like symptoms, demonstrating their potential to survive, integrate, and contribute to neuronal function over a 14-week period.
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As federal strategic plans prioritize increasing diversity within the biomedical workforce, and STEM training and outreach programs seek to recruit and retain students from historically underrepresented populations, there is a need for interrogation of traditional demographic descriptors and careful consideration of best practices for obtaining demographic data. To accelerate this work, equity-focused researchers and leaders from STEM programs convened to examine approaches for measuring demographic variables. Gender, race/ethnicity, disability, and disadvantaged background were prioritized given their focus by federal funding agencies.

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Background: Cancer health research relies on large-scale cohorts to derive generalizable results for different populations. While traditional epidemiological cohorts often use costly random sampling or self-motivated, preselected groups, a shift toward health system-based cohorts has emerged. However, such cohorts depend on participants remaining within a single system.

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The Healthy Oregon Project (HOP) is a statewide effort that aims to build a large research repository and influence the health of Oregonians through providing no-cost genetic screening to participants for a next-generation sequencing 32-gene panel comprising genes related to inherited cancers and familial hypercholesterolemia. This type of unbiased population screening can detect at-risk individuals who may otherwise be missed by conventional medical approaches. However, challenges exist for this type of high-throughput testing in an academic setting, including developing a low-cost high-efficiency test and scaling up the clinical laboratory for processing large numbers of samples.

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A cancer research training program explored different approaches for staffing their in-person and virtual programs for high school students. The inclusion of undergraduate near-peer mentors had a universal benefit when implemented across in-person and virtual training programs of one- and ten-week durations. Benefits are described for four stakeholder groups: the high school trainees, program staff, scientist partners, and peer mentors themselves.

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