Publications by authors named "L K M Loh"
The human fetal immune system starts to develop in the first trimester and likely plays a crucial role in fetal development and maternal-fetal tolerance. Innate lymphoid cells (ILCs) are the earliest lymphoid cells to arise in the human fetus. ILCs consist of natural killer (NK) cells, ILC1s, ILC2s, and ILC3s that all share a common lymphoid origin.
View Article and Find Full Text PDFFactors associated with burnout among healthcare workers in a Singaporean hospital during the post-COVID era.
East Asian Arch Psychiatry
September 2024
Background: This study aimed to investigate factors associated with burnout among healthcare workers (HCWs) in a tertiary hospital in Singapore.
Methods: All HCWs from the Singapore General Hospital were invited to participate in a survey using a secure online platform. Participant demographic data were collected.
Point defects in crystalline solids behave as optically addressable individual quantum systems when present in sufficiently low concentrations. In two-dimensional (2D) semiconductors, such quantum defects hold potential as versatile single photon sources. Here, we report the synthesis and optical properties of Nb-doped monolayer WS in the dilute limit where the average spacing between individual dopants exceeds the optical diffraction limit, allowing the emission spectrum to be studied at the single-dopant level.
View Article and Find Full Text PDFArticle Synopsis
- Genetic variation in immune responses, particularly related to HLA and KIR genes, influences how First Nations peoples are affected by infectious diseases.
- HLA-A24:02 and the KIR3DL1 receptor have evolved in First Nations populations, showcasing a significant adaptation through natural selection.
- The KIR3DL1114 allele, unique to Oceania, demonstrates a strong interaction with HLA-A24:02, which enhances immune response, thus highlighting the importance of immunogenetic studies in understanding disease susceptibility.
Article Synopsis
- The "innate-like" T cell compartment, referred to as T, consists of diverse T cells that bridge innate and adaptive immunity and is analyzed using advanced techniques like single-cell RNA sequencing.
- In human blood, most T cells exhibit an effector program driven by unique transcription factors, contrasting with conventional T cells, while varied developmental stages are observed in thymic T cells.
- Unlike mice, human T cells do not form multiple effector subsets but show a mix of type 1 and type 17 effector potential, revealing key differences in immune regulation between species.