The role of carbohydrate in thyrotropin action assessed by a novel approach using enzymatic deglycosylation.

Deglycosylation of thyrotropin (TSH) and gonadotropins by chemical methods virtually abolishes their biological activity without impairing receptor binding activity. Recent reports have suggested that enzymatic deglycosylation, using endoglycosidases caused a much smaller decrease, if any, in the potency of the glycoprotein hormones without altering the Vmax. However, in these studies complete removal of the carbohydrate chains from the hormones was not unequivocally documented.

The closure index: prediction of long-term patency of femoropopliteal vein grafts.

Of 227 reversed saphenous vein femoropopliteal graft procedures performed between January 1, 1974, and December 31, 1978 limbs (72 patients) and postoperative angiograms (37% of total) were reviewed to assess the influence of graft diameter, length, and runoff on patency rates. Patient characteristics were as follows: mean age was 64 years; 73% were men; 22% were diabetics; and 68% had ischemia as the indication. Patients were followed from 26 to 86 months (mean 52 months).

Failure of autogenous reversed saphenous vein femoropopliteal grafting: pathophysiology and prevention.

As part of a study of various clinical, pathologic, and hemodynamic factors on both short- and long-term patency of autogenous reversed saphenous vein femoropopliteal bypass grafts, an early and recent series of patients from Yale University School of Medicine is compared with four other index series. Review and comparison reveals a well-recognized pattern of graft failure that occurs in three definable periods. The closure rate differs between periods and among series and allows a delineation of the responsible factors.

Splenic abscess caused by Propionibacterium acnes.

A 59-year-old male diabetic was admitted with an acute myocardial infarction and had recurrent. Propionibacterium acnes bacteremia. Fifteen months after the initial admission a splenectomy was required for removal of a large splenic abscess caused by P.