Screening for rheumatoid arthritis-associated interstitial lung disease-a Delphi-based consensus statement.

Objective: Rheumatoid arthritis-associated interstitial lung disease (RA-ILD) is a major driver of premature mortality in patients with rheumatoid arthritis (RA). Detection of RA-ILD is crucial but requires awareness among the treating physicians. To date, however, there is no international recommendation concerning screening for ILD in RA patients.

efficacy proof of concept of a large-size bioprinted dermo-epidermal substitute for permanent wound coverage.

An autologous split-thickness skin graft (STSG) is a standard treatment for coverage of full-thickness skin defects. However, this technique has two major drawbacks: the use of general anesthesia for skin harvesting and scar sequelae on the donor site. In order to reduce morbidity associated with STSG harvesting, researchers have developed autologous dermo-epidermal substitutes (DESs) using cell culture, tissue engineering, and, more recently, bioprinting approaches.

Boosting Entanglement Generation in Down-Conversion with Incoherent Illumination.

Entangled photons produced by spontaneous parametric down-conversion have been of paramount importance for our current understanding of quantum mechanics and advances in quantum information. In this process, the quantum correlations of the down-converted photons are governed by the optical properties of the pump beam illuminating the nonlinear crystal. Extensively, the pump beam has been modeled by either coherent beams or by the well-known Gaussian-Schell model, which leads to the natural conclusion that a high degree of optical coherence is required for the generation of highly entangled states.

CDK1-CCNB1 creates a spindle checkpoint-permissive state by enabling MPS1 kinetochore localization.

Spindle checkpoint signaling is initiated by recruitment of the kinase MPS1 to unattached kinetochores during mitosis. We show that CDK1-CCNB1 and a counteracting phosphatase PP2A-B55 regulate the engagement of human MPS1 with unattached kinetochores by controlling the phosphorylation status of S281 in the kinetochore-binding domain. This regulation is essential for checkpoint signaling, since MPS1 is not recruited to unattached kinetochores and fails to support the recruitment of other checkpoint proteins.

Interlinked bistable mechanisms generate robust mitotic transitions.

The transitions between phases of the cell cycle have evolved to be robust and switch-like, which ensures temporal separation of DNA replication, sister chromatid separation, and cell division. Mathematical models describing the biochemical interaction networks of cell cycle regulators attribute these properties to underlying bistable switches, which inherently generate robust, switch-like, and irreversible transitions between states. We have recently presented new mathematical models for two control systems that regulate crucial transitions in the cell cycle: mitotic entry and exit, and the mitotic checkpoint.