Publications by authors named "L K Gibbons"
Introduction: We investigated whether the cerebellum develops neuropathology that correlates with well-accepted Alzheimer's disease (AD) neuropathological markers and cognitive status.
Methods: We studied cerebellar cytoarchitecture in a cohort (N = 30) of brain donors. In a larger cohort (N = 605), we queried whether the weight of the contents of the posterior fossa (PF), which contains primarily cerebellum, correlated with dementia status.
The prevalence of depression and anxiety in patients with metastatic disease to the spine.
J Craniovertebr Junction Spine
September 2024
Article Synopsis
- The study highlights that about 20% of patients with metastatic spine disease experience depression, while approximately 17% struggle with anxiety, emphasizing the need for mental health awareness in this population.
- Data was collected from patients over 18 years old who underwent treatment for metastatic spinal disease from 2017 to 2022, revealing a significant number of both depression and anxiety diagnoses among them.
- The findings suggest that spine surgeons should actively screen for mental health issues in patients with spinal metastases to ensure timely referrals for psychological support.
Introduction: Loneliness has a rising public health impact, but research involving neuropathology and representative cohorts has been limited.
Methods: Inverse odds of selection weights were generalized from the autopsy sample of Rush Alzheimer's Disease Center cohorts (N = 680; 89 ± 9 years old; 25% dementia) to the US-representative Health and Retirement Study (N = 8469; 76 ± 7 years old; 5% dementia) to extend external validity. Regressions tested cross-sectional associations between loneliness and (1) Alzheimer's disease (AD) and cerebrovascular pathology; (2) five cognitive domains; and (3) relationships between pathology and cognition, adjusting for depression.
Background: There is limited evidence from antimicrobial stewardship programmes in less-resourced settings. This study aimed to improve the quality of antibacterial prescriptions by mitigating overuse and promoting the use of narrow-spectrum agents in intensive care units (ICUs) in a middle-income country.
Methods: We established a quality improvement collaborative (QIC) model involving nine Argentine ICUs over 11 months with a 16-week baseline period (BP) and a 32-week implementation period (IP).
Background: Conflicting research on retinal biomarkers of Alzheimer's disease and related dementias (AD/ADRD) is likely related to limited sample sizes, study design, and protocol differences.
Objective: The prospective Eye Adult Changes in Thought (Eye ACT) seeks to address these gaps.
Methods: Eye ACT participants are recruited from ACT, an ongoing cohort of dementia-free, older adults followed biennially until AD/ADRD, and undergo visual function and retinal imaging assessment either in clinic or at home.