Publications by authors named "L K Dobrodeeva"
Article Synopsis
- The study investigates how the immune system and blood transport components of people in the Arctic region of Russia adapt to environmental stressors, revealing the body's resilience and functionality.
- The research analyzed blood samples from 191 Arctic residents, measuring indicators like hemoglobin levels, immune cell activity, and cytokine concentrations, using various statistical methods.
- Findings showed high rates of erythrocytosis, thrombocytosis, and leukocytosis among locals, while highlighting reduced active phagocytes and specific lymphocyte populations, alongside increased levels of pro-inflammatory cytokines and circulating immune complexes.
Polyphenols (PP) found in brown algae are known for their wide range of biological activities including noteworthy antitumor properties. This article presents a method for obtaining an active polyphenolic extract from the Arctic alga Fucus vesiculosus with 98% purity and radical scavenging activity equivalent to 862 mg of ascorbic acid per gram of extract. Immunostimulant effects of polyphenols were assessed in vitro using venous blood from two groups of people: healthy people (HP) and people with chronic undifferentiated lymphocytic leukemia (LP).
View Article and Find Full Text PDFSpecific antibodies to food antigens are detected both in healthy individuals and in various pathologies, including those of the gastrointestinal tract, neuro- and autoimmune diseases. In fact, there are no studies concerning the level of specific IgG to food antigens in metabolic syndrome. A comparative analysis of the concentration of specific IgG to food antigens in patients with metabolic syndrome and healthy people was carried out.
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- The study aimed to investigate the immune status of the Kola Saami and Russians living in the extreme climates of the Far North, focusing on how climate and genetic factors affect immunological reactivity.
- Researchers conducted a detailed blood analysis on 67 Saami and 81 Russians, examining various immune cells, cytokines, and antibodies through advanced immunological techniques.
- Results indicated that the Saami exhibited lower leukocyte counts and deficiencies in certain immune components, while the Russians showed higher levels of various immune markers, suggesting distinct immune profiles between the two populations.
One of the main issues of the peculiarities of the immune reactions of the gastrointestinal tract is the mechanisms of ensuring tolerance to food antigens. Concentrations of antibodies to food antigens actually reflect the state of the intestinal mucosa barrier function, and the degree of penetration of antigens into the blood determines the level of immune response to them. of the study was to determine the risk criteria for violation of tolerance to food antigens.
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