A comprehensive insights of cancer immunotherapy resistance.

Cancer is a major global health issue that is usually treated with multiple therapies, such as chemotherapy and targeted therapies like immunotherapy. Immunotherapy is a new and alternative approach to treating various types of cancer that are difficult to treat with other methods. Although immune checkpoint inhibitors have shown promise for long-term efficacy, they have limited effectiveness in common cancer types such as breast, prostate, and lung.

Amoebae: beyond pathogens- exploring their benefits and future potential.

Amoebae, fascinatingly diverse protists, showcase a dual nature that positions them as both friends and foes in our world. These organisms, defined by their distinctive pseudopodia, span a spectrum from harmful to helpful. On the darker side, species like pose serious health risks, causing intestinal and liver diseases, while the infamous "brain-eating" leads to fatal primary amoebic meningoencephalitis (PAM), with a daunting 97% mortality rate.

Assessment of delayed termination of pregnancy in India: Evidence from National Family Health Survey, 2019-21.

Background: Compared to first trimester abortions, those in the second trimester significantly contribute to maternal morbidity and mortality, particularly in low- and middle-income settings where access to safe second trimester abortion services is restricted. This study aimed to evaluate the prevalence and factors associated with induced second trimester abortions in India.

Data And Methods: Retrospective calendar data for 7,696 women aged 15-49 years from fifth round of National Family Health Survey (2019-2021) was used for the study.

Malignant thyroid neoplasm with ectopic Cushing's syndrome.

An adult man in his 30s with newly diagnosed diabetes mellitus and hypertension presented with a 33 lb weight gain, generalised swelling and classic Cushingoid features, including proximal muscle weakness, easy bruisability, wide violaceous striae and a painless, progressively enlarging right-sided neck swelling over the past month. Physical examination revealed a 4×4 cm thyroid mass, facial plethora and dorsocervical fat pads. Laboratory investigations confirmed hypercortisolism with elevated cortisol and Adrenocorticotropic Hormone(ACTH), with non-suppression on dexamethasone suppression tests.

Quantitative analysis of antibacterial efficacy of herbal irrigants against endodontic microflora - A clinical study.

Aims: The study aimed to assess the antimicrobial effectiveness of green tea and neem extract compared to sodium hypochlorite (NaOCl) against various root canal microorganisms.

Materials And Methods: Thirty patients with pulpal necrosis were selected, providing 60 samples before and after irrigation. Groups were assigned as follows: Group A: 3% NaOCl (control), Group B: green tea, and Group C: neem extract.