Publications by authors named "L K Christenson"
Article Synopsis
- Neuropeptides play a crucial role in brain functions related to feeding and behavior, but many details about their interactions in the awake brain remain unclear.
- The study focuses on how specific neurons in the hypothalamus react to different neuropeptides to regulate eating and the feeling of fullness.
- Results show that the release of hunger-related and satiety-related neuropeptides can either compete or cooperate to control important signaling pathways, helping to gradually promote feelings of fullness during meals.
Article Synopsis
- Exosomes are small membrane-bound vesicles playing key roles in various biological processes, and an innovative transgenic mouse model called Exomap1 was developed to study their biology.
- The Exomap1 mouse expresses a fluorescent exosome marker (HsCD81mNG) specifically when induced by Cre recombinase, allowing for tracking and analysis of exosome secretion and composition.
- Findings showed distinct contributions from different cell types to exosome populations, with neurons contributing ~1% and hepatocytes ~15% to plasma exosomes, affirming the model's utility for exosome research.
Introduction: Premenopausal bilateral oophorectomy (PBO) is associated with later-life cognition, but the underlying brain changes remain unclear. We assessed the impact of PBO and PBO age on white matter integrity.
Methods: Female participants with regional diffusion tensor imaging (DTI) metrics of fractional anisotropy (FA) and mean diffusivity (MD) were included (22 with PBO < 40 years; 43 with PBO 40-45 years; 39 with PBO 46-49 years; 907 referents without PBO < 50 years).
Introduction: Female-specific reproductive factors and exogeneous estrogen use are associated with cognition in later life. However, the underlying mechanisms are not understood. The present study aimed to investigate the effect of reproductive factors on neuroimaging biomarkers of Alzheimer's disease (AD) and cerebrovascular pathologies.
View Article and Find Full Text PDFObjective: Menopause adversely impacts systemic energy metabolism and increases the risk of metabolic disease(s) including hepatic steatosis, but the mechanisms are largely unknown. Dosing female mice with vinyl cyclohexene dioxide (VCD) selectively causes follicular atresia in ovaries, leading to a murine menopause-like phenotype.
Methods: In this study, we treated female C57BL6/J mice with VCD (160 mg/kg i.