[Studying hemostimulating activity of new compound BIV-30 under conditions of cyclophosphan-induced myelosupression].

The effects of the new chemical substance BIV-30 on bone marrow hemopoiesis has been studied in laboratory mices on the background of myelosupression induced by a single intraperitoneal injection of cyclophosphan in a dose 160 mg/kg. The injection of BIV-30 significantly accelerated lymphocyte, monocyte, granulocyte regeneration branches of bone-marrow hemopoiesis. These results showed evidence of the hemostimulating activity of BIV-30 on the model of bone-marrow hemopoiesis deficiency.

[Effect of a novel compound BIV-30 on bone-marrow hematopoiesis in myelosuppression induced by lead acetate].

The Intraperitoneal injection of lead acetate in a daily doze of 50 mg/kg for 10 days led to the development of myelosuppression of the bone-marrow pool in mice. On the background of this immunodepressive syndrome, the treatment with B1V-309 azaheterocycle during 3 days reliably accelerated the regeneration of neutrophiles, lymphocytes, and monocyte cells in bone marrow. The results shown evidence of the hemostimulating activity of BIV-30 on the model of bone-marrow hemopoiesis deficiency.