Early career psychiatrists' perceptions of and training experience in electroconvulsive therapy: A cross-sectional survey across Europe.

Background: Electroconvulsive therapy (ECT) is a safe and effective treatment for several major psychiatric conditions, including treatment-resistant depression, mania, and schizophrenia; nevertheless, its use remains controversial. Despite its availability in some European countries, ECT is still rarely used in others. This study aims to investigate the experiences and attitudes of early career psychiatrists (ECPs) across Europe towards ECT and to examine how their exposure to ECT influences their perceptions.

DNA targeting by compact Cas9d and its resurrected ancestor.

Type II CRISPR endonucleases are widely used programmable genome editing tools. Recently, CRISPR-Cas systems with highly compact nucleases have been discovered, including Cas9d (a type II-D nuclease). Here, we report the cryo-EM structures of a Cas9d nuclease (747 amino acids in length) in multiple functional states, revealing a stepwise process of DNA targeting involving a conformational switch in a REC2 domain insertion.

Do low-risk patients really need follow-up after a pulmonary embolism?

Background: The British Thoracic Society recommend that pulmonary embolism (PE) patients with low-risk Pulmonary Embolism Severity Index (PESI) scores are considered for outpatient (OP) management, in settings where robust pathways for follow-up and monitoring exist.

Methods: Retrospective cohort study. We reviewed the electronic records of 109 consecutive PE patients considered appropriate for OP management.

Graduate nurses caring for people living with dementia: A scoping review.

Background: Adequate dementia care knowledge of graduate nurses is essential for the wellbeing of both people living with dementia as well as the graduate nurses caring for them. Little is known about the dementia care knowledge, experience or confidence of graduate nurses caring for people living with dementia. This paper aims to review the available literature on graduate nurses caring for people living with dementia.

Evaluation of the efficiency of SmartArch, copper-NiTi, and NiTi archwires in resolving mandibular anterior crowding: A double-blinded randomized controlled trial.

Background/objective: Resolution of crowding remains a chief concern for patients seeking orthodontic treatment. The choice of the initial aligning archwire is crucial for achieving treatment success. Nickel-titanium (NiTi) archwires have been the first choice since their introduction.