Skeletal muscle disorders as risk factors for type 2 diabetes.

The incidence and prevalence of muscular disorders and of type 2 diabetes (T2D) is increasing and both represent highly significant healthcare problems, both economically and compromising quality of life. Interestingly, skeletal muscle dysfunction and T2D share some commonalities including dysregulated glucose homeostasis, increased oxidative stress, dyslipidemia, and cytokine alterations. Several lines of evidence have hinted to a relationship between skeletal muscle dysfunction and T2D.

Complications in anterior cruciate ligament reconstruction.

Anterior cruciate ligament reconstruction (ACLR), despite its effectiveness in restoring knee stability and function, can have associated morbidity. The most frequent complications are technical errors, which have been described during graft harvesting, tunnel placement or graft fixation. The most serious complications are neurovascular injuries, arthrofibrosis and infections.

Proteolytic profile and nematicidal potential of proteases produced by Pleurotus djamor in coprocultures.

The aim of this study was to evaluate the proteolytic profile of the cell-free crude extract (CFCE) of Pleurotus djamor and its nematicidal action on Haemonchus spp. and Trichostrongylus spp. larvae in coprocultures.

Plate tectonics, cold adaptation and long-distance range expansion to remote archipelagos and the high Andes as drivers of a circumantarctic freshwater arthropod radiation.

Disjunct distributions, characterised by spatially separated populations of related species, offer insights into historical biogeographic patterns and evolutionary processes. This study investigates the evolutionary history of the diving beetle subfamily Lancetinae through a phylogenomic approach incorporating ultraconserved elements (UCEs) and heritage genetic markers. Our findings support an early Miocene origin for Lancetinae, with subsequent diversification influenced by historical vicariance events and long-distance dispersal.

Generation and capture of naphthoquinonynes: a new frontier in the development of trypanocidal quinones aryne chemistry.

The regioselective synthesis of functionalized naphthoquinones the formation and capture of naphthoquinonynes has been used to prepare trypanocidal compounds. The target compounds are functionalized on the aromatic ring, leaving the quinoidal ring intact. Using this technique, eighteen functionalized naphthoquinones were succesfull obtained, divided in two main groups: the first scope using -nucleophiles, and the second scope using pyridine -oxides, with yields up to 74%.