Captopril and bronchial reactivity.

In order to assess the effect of captopril on bronchial reactivity, 16 consecutive patients with asthma and hypertension were randomized in a double-blind crossover study, with increasing doses of placebo or captopril for 4 week periods. Forced expiratory flow (FEV1) and a dose-response curve with methacholine (PD20) were measured before and after treatment . Effective control of hypertension was achieved in all patients on captopril (P less than 0.