Publications by authors named "L Joseph Melton"
Article Synopsis
- Recent advancements in aging research and drug discovery connect basic research with clinical applications, aiming to promote healthy longevity in humans.* -
- The Aging Research and Drug Discovery Meeting in 2023 highlighted key areas such as AI, biomarkers, geroscience, and clinical trials focused on enhancing healthspan.* -
- The meeting emphasized the importance of combining generative AI with innovative biological technologies to tackle age-related diseases and extend healthy lifespans.*
Anticoagulant rodenticide exposure in common buzzards: Impact of new rules for rodenticide use.
Sci Total Environ
September 2024
Article Synopsis
- Rodenticides are important for managing rodent populations, but they also pose a risk to birds of prey, like buzzards, which can be unintentionally poisoned.
- In the UK, a stewardship scheme was introduced in 2016 to reduce the risk of bird exposure to second generation anticoagulant rodenticides (SGARs), but a study found no significant decrease in SGAR exposure among buzzards after this change.
- The study revealed a troubling increase in brodifacoum exposure and multiple SGARs in buzzards post-stewardship, suggesting that the current measures may not be effective and further revisions may be needed.
Nonstructural protein 1 (nsp1) of the severe acute respiratory syndrome coronavirus (SCOV1 and SCOV2) acts as a host shutoff protein by blocking the translation of host mRNAs and triggering their decay. Surprisingly, viral RNA, which resembles host mRNAs containing a 5'-cap and a 3'-poly(A) tail, escapes significant translation inhibition and RNA decay, aiding viral propagation. Current literature proposes that, in SCOV2, nsp1 binds the viral RNA leader sequence, and the interaction may serve to distinguish viral RNA from host mRNA.
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