Publications by authors named "L Joerg"
Article Synopsis
- Toxic epidermal necrolysis (TEN) is a severe and potentially deadly skin reaction caused by common medications, featuring rapid skin detachment due to cell death, with no effective treatments currently available.
- Researchers used deep visual proteomics to analyze skin biopsies from TEN patients, identifying significant changes in proteins related to type I and II interferon signaling and activated phosphorylated STAT1, which are believed to drive the condition.
- The study found that using JAK inhibitors, like tofacitinib and baricitinib, effectively reduced skin damage in both mouse models and human patients with TEN, indicating these pathways could be targeted for potential new treatments.
Keloids are characterized histologically by excessive fibroblast proliferation and connective tissue deposition, and clinically by scar tissue extending beyond the original site of skin injury. These scars can cause pruritus, pain, physical disfigurement, anxiety, and depression. As a result, keloid patients often have a diminished quality of life with a disproportionate burden on ethnic minorities.
View Article and Find Full Text PDFQuantity increase and functional affinity/avidity decrease of anti-FcεRI and anti-IgE autoantibodies in chronic spontaneous urticaria.
Eur Ann Allergy Clin Immunol
November 2024
Patients with autoimmune forms of chronic spontaneous ur-ticaria (aiCSU) exhibit autoantibodies against the high-affinity IgE recep-tor (FcεRI) and IgE. As the presence of these autoantibodies does not cor-relate with disease activity, the functional affinity/avidity may be relevant in aiCSU. This exploratory study aimed to characterize the quantity and avidity of autoantibodies against IgE and FcεRI over 6 months.
View Article and Find Full Text PDFBackground: In aortic stenosis (AS), estimated glomerular filtration rate (eGFR) is an important prognostic marker but its haemodynamic determinants are unknown. We investigated the correlation between eGFR and invasive haemodynamics and long-term mortality in AS patients undergoing aortic valve replacement (AVR).
Methods: We studied 503 patients [median (interquartile range) age 76 (69-81) years] with AS [indexed aortic valve area .
Aims: Blood pressure (BP) targets in patients with aortic stenosis (AS) are controversial. This study sought to describe the haemodynamic profile and the clinical outcome of severe AS patients with low versus high central meaarterial pressure (MAP).
Methods And Results: Patients with severe AS (n = 477) underwent right and left heart catheterization prior to aortic valve replacement (AVR).