Two-scale analysis of a tight gas sandstone.

Tight gas sandstones are low porosity media, with a very small permeability (i.e., below 1 mD).

Peptidyl-oligonucleotide conjugates demonstrate efficient cleavage of RNA in a sequence-specific manner.

Described here is a new class of peptidyl-oligonucleotide conjugates (POCs) which show efficient cleavage of a target RNA in a sequence-specific manner. Through phosphoramidate attachment of a 17-mer TΨC-targeting oligonucleotide to amphiphilic peptide sequences containing leucine, arginine, and glycine, zero-linker conjugates are created which exhibit targeted phosphodiester cleavage under physiological conditions. tRNA(Phe) from brewer's yeast was used as a model target sequence in order to probe different structural variants of POCs in terms of selective TΨC-arm directed cleavage.

Tax gene expression and cell cycling but not cell death are selected during HTLV-1 infection in vivo.

Background: Adult T cell leukemia results from the malignant transformation of a CD4+ lymphoid clone carrying an integrated HTLV-1 provirus that has undergone several oncogenic events over a 30-60 year period of persistent clonal expansion. Both CD4+ and CD8+ lymphocytes are infected in vivo; their expansion relies on CD4+ cell cycling and on the prevention of CD8+ cell death. Cloned infected CD4+ but not CD8+ T cells from patients without malignancy also add up nuclear and mitotic defects typical of genetic instability related to the expression of the virus-encoded oncogene tax.

[COPD in elderly patients].

Introduction: Patients with COPD are growing in number and are getting older, with 75% of deaths occurring after the age of 75; the proportion of women is increasing.

State Of The Art: There are few data regarding COPD in the elderly. The related medical and social demands are significant and rise as age and respiratory disability increase.