Publications by authors named "L Jansson"
Article Synopsis
- - The study examines the neurobehavioral functioning of neonates exposed to buprenorphine/naloxone during pregnancy, addressing the lack of research on the effects of this medication combination on infants.
- - Data was collected from mothers undergoing treatment for opioid use disorder, with the neonates assessed at three different points in their first month of life using the NICU Network Neurobehavioral Scale (NNNS).
- - Results highlighted various neurobehavioral domains affected in these infants and identified maternal factors, such as high rates of smoking and psychiatric disorders, that may impact neonatal development.
Article Synopsis
- The study aimed to compare the levels of specific proteolytic enzymes (MMP-1, MMP-2, MMP-3) and inflammatory mediators (OPN, PTX3, TSLP) in the crevicular fluid from healthy, periodontitis-affected, and peri-implantitis sites to understand their unique host responses.
- Researchers collected and analyzed samples from 163 patients, finding that levels of the studied markers were significantly higher in diseased sites compared to healthy ones, but no major differences were noted between periodontitis and peri-implantitis sites.
- MMP-2 and TSLP displayed the highest diagnostic potential for distinguishing issues at implant sites, while OPN had the best diagnostic accuracy
In recent years, more sophisticated DNA technologies for genotyping have enabled considerable progress in various fields such as clinical genetics, archaeogenetics and forensic genetics. DNA samples previously rejected as too challenging to analyze due to low amounts of degraded DNA can now provide useful information. To increase the chances of success with the new methodologies, it is crucial to know the fragment size of the template DNA molecules, and whether the DNA in a sample is mostly single or double stranded.
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- The study investigates whether socioeconomic factors affect the referral delay to vascular services and healing time for patients with venous ulcers (VUs).
- A total of 63 patients participated, with the analysis revealing that socioeconomic factors were not significant in delaying referrals or healing time post-intervention.
- Key risk factors for delayed referrals included recurrent VUs, walking impairment, and dependence on home care, whereas 85% of patients healed without recurrence within a year.
Gestational buprenorphine-naloxone exposure and fetal neurobehavior.
Neurotoxicol Teratol
August 2024
Background: Buprenorphine-naloxone treatment may confer substantial benefits for the treatment of opioid use disorder (OUD) during pregnancy including lower risk for overdose/death, less diversion potential and reduced use of other substances. Treatment may also result in less severe Neonatal Abstinence Syndrome (NAS), but little is known about the effects of this medication on fetal neurodevelopment.
Methods: The purpose of the current study is to evaluate neurobehaviors among fetuses exposed to buprenorphine-naloxone at four time points over the second and third trimesters of gestation in pregnant women with OUD on buprenorphine-naloxone therapy.