Publications by authors named "L Janker"
Background: In the context of the coronavirus pandemic, countless face-to-face events as well as medical trainings were cancelled or moved to online courses, which resulted in increased digitalization in many areas. In the context of medical education, videos provide tremendous benefit for visualizing skills before they are practised.
Methods: Based on a previous investigation of video material addressing epidural catheterization available on the YouTube platform, we aimed to investigate new content produced in the context of the pandemic.
Article Synopsis
- Ulcerative colitis (UC) is a chronic condition with increasing prevalence and uncertain causes, and advanced molecular profiling may reveal important insights into its mechanisms and remission features.
- The study involved analyzing tissue and plasma samples from UC patients using mass spectrometry to identify changes in proteins and metabolites during active disease and remission, compared to healthy individuals.
- Results showed that inflammation involved various immune cells and indicated ongoing microvascular damage and platelet abnormalities even during remission, suggesting persistent molecular markers associated with UC.
Article Synopsis
- - A series of six lipophilic molybdenocenes with different active ligands were created and analyzed using techniques like NMR and X-ray crystallography.
- - The new compounds showed much higher cytotoxic effects in lab tests compared to their non-Cp counterparts.
- - Experiments in living organisms indicated that one particular compound inhibited tumor growth and affected protein regulation related to cell structure and energy production.
Janus kinase Tyk2 is implicated in cancer immune surveillance, but its role in solid tumors is not well defined. We used Tyk2 knockout mice (Tyk2) and mice with conditional deletion of Tyk2 in hematopoietic (Tyk2) or intestinal epithelial cells (Tyk2) to assess their cell type-specific functions in chemically induced colorectal cancer. All Tyk2-deficient mouse models showed a higher tumor burden after AOM-DSS treatment compared to their corresponding wild-type controls (Tyk2 and Tyk2), demonstrating tumor-suppressive functions of Tyk2 in immune cells and epithelial cancer cells.
View Article and Find Full Text PDFTarget identification remains a critical challenge in inorganic drug discovery to deconvolute potential polypharmacology. Herein, we describe an improved approach to prioritize candidate protein targets based on a combination of dose-dependent chemoproteomics and treatment effects in living cancer cells for the rhenium tricarbonyl compound TRIP. Chemoproteomics revealed 89 distinct dose-dependent targets with concentrations of competitive saturation between 0.
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