MORPHOLOGICAL CHANGES OF THE HEPATIC PORTAL TRACTS IN EXPERIMENTALLY INDUCED CHOLESTASIS.

The dynamics of morphological changes developed in liver and bile ducts in biliary obstruction are well studied in the animal models of biliary obstruction, however,the data on the morphology of the portal tracts are scarce. The aim of the research was to study the structure of the portal tracts and interrelationship of their structural components in experimental biliary obstruction. The investigation was conducted on albino Wistar rats weighing 200-250 g, undergone biliary obstruction by common bile duct ligation (CBDL).

[; ADAPTATION OF THE BILE DUCTS OF THE PORTAL TRIAD IN CASE OF MECHANICAL CHOLESTASIS (REVIEW)].

In case of mechanical cholestasis, along with stagnation in the veins and bile ducts, lymph production increases, which contributes to the accumulation of ascitic fluid. In the peribiliaryareas, where the extramural biliary glands are located, an accumulation of lymphatic vessels has been observed in all the preparations.In these same areas, a contrast-enhanced microtomography showed transition of the ink-gelatin contrast agents (using gelatin and India ink) from the extramural part of the mucous glands to the lumen of the lymphatic capillaries and blood vessels.