Publications by authors named "L Jacquot Thierry"
Objectives: To evaluate the oncological efficacy and complications of cryoablation (CA) in treating lung metastases from colorectal cancer (CRC) at the lung periphery.
Materials And Methods: The inclusion criteria for this bicenter retrospective study included patients with histologically confirmed CRC, with radiologically confirmed lung metastases at the periphery of the lung (distance of less than or equal to 2 cm from the costal, diaphragmatic, or cervical pleura) treated with CA between January 2017 and June 2022. Patients with intra-parenchymal metastases or metastases close to the mediastinal pleura and patients without follow-up were excluded.
Article Synopsis
- - Bioaugmentation with Pseudomonas putida enhanced the ability of sunflowers to extract copper (Cu) from vineyard soils, increasing Cu concentration in roots by 93% and in shoots by 17%, while also boosting sunflower biomass by 30% to 60%.
- - The study focused on the mechanisms behind copper transfer from soil to plants, highlighting the role of siderophores, particularly pyoverdine (Pvd), which formed a 1:1 complex with Cu, aiding its mobilization and availability for the sunflowers.
- - Interestingly, carbonated soils did not enhance the mobilization of trace elements as expected, suggesting that further optimization could involve strategies to enhance the dissociation of the Pvd-C
For the investigation of protein-ligand interaction patterns, the current accessibility of a wide variety of sampling methods allows quick access to large-scale data. The main example is the intensive use of molecular dynamics simulations applied to crystallographic structures which provide dynamic information on the binding interactions in protein-ligand complexes. Chemical feature interaction based pharmacophore models extracted from these simulations, were recently used with consensus scoring approaches to identify potentially active molecules.
View Article and Find Full Text PDFExtracts of Citri reticulatae pericarpium (PCR) are commonly used in the Traditional Chinese Medicine. The quality control of PCR is currently performed by single marker analysis, which can hardly describe the complexity of such natural samples. In this study, a fingerprint methodology for PCR based on high-performance liquid chromatography (HPLC) was developed and validated.
View Article and Find Full Text PDFArticle Synopsis
- The adenine nucleotide translocator (ANT) plays a key role in several important cellular processes, such as energy supply, maintaining mitochondrial DNA, and regulating programmed cell death (apoptosis).
- The paper discusses six different structures of ANT1, noting that changes in these structures are influenced by the cell's energy needs and help manage oxidative phosphorylation (OXPHOS) activity.
- It further reveals that under low respiratory chain activity, the pro-apoptotic protein Bax can trigger a significant release of cytochrome c from specific ANT1 structures, highlighting the connection between ANT’s structural changes and apoptosis depending on energy levels.