Publications by authors named "L J Schiff"
Background: Half of perimenopausal women experience depressive symptoms, including anhedonia. Anhedonia is associated with dysregulation of the frontostriatal circuit. Both the frontrostriatal circuit and depression may be regulated by the reproductive hormone estradiol (E2).
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- * The research focused on autistic females aged 35-70 to examine the prevalence of symptomatic menopause and associated health conditions among them, finding about 4% reported symptomatic menopause.
- * Results showed that those with ADHD, anxiety, depression, migraines, and other conditions had higher rates of symptomatic menopause, highlighting the need for better support and discussions around these issues in healthcare settings.
Synthetic lethality provides an attractive strategy for developing targeted cancer therapies. For example, cancer cells with high levels of microsatellite instability (MSI-H) are dependent on the Werner (WRN) helicase for survival. However, the mechanisms that regulate WRN spatiotemporal dynamics remain poorly understood.
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