Publications by authors named "L J Savic"
Neuromuscular blocking agents are a common cause of perioperative hypersensitivity. The sensitivity and specificity of skin tests and in vitro tests in this context have not been determined conclusively, which poses a barrier to accurate diagnosis. Use of challenge testing represents a promising development in this field and a key tool in confirming tolerance to an alternate neuromuscular blocking agent for use in future anaesthesia.
View Article and Find Full Text PDFArticle Synopsis
- The study examined the effectiveness of using multiparametric MRI (mpMRI) as a diagnostic tool for identifying clinically significant prostate cancer (csPCa) and its impact on managing biopsy decisions in men suspected of having the disease.
- Conducted over three years at multiple urology practices in Berlin, the trial monitored participants with either positive or negative mpMRI results, allowing for a better understanding of patient outcomes and the safety of the protocol.
- Results indicated that a significant number of men avoided unnecessary biopsies over time, with a small percentage of those initially deemed negative later diagnosed with csPCa, suggesting the monitoring strategy may be feasible and safe for patients.
Very small superparamagnetic iron oxide nanoparticles (VSOPs) show diagnostic value in multiple diseases as a promising MRI contrast agent. Macrophages predominantly ingest VSOPs, but the mechanism remains unclear. This study identifies differences in VSOP uptake between pro-inflammatory M1 and anti-inflammatory M2 macrophages and explores the role of the pericellular glycocalyx.
View Article and Find Full Text PDFThis retrospective study was aimed at characterizing vascular malformations (VMFs) presenting for minimally invasive image-guided therapies (MIT) at a tertiary-care center and evaluating treatment regimens and image-based outcomes using MRI. We analyzed demographic, disease-related, and radiologic features of VMFs presenting to interventional radiology between May 2008 and August 2020 using compendium vascular anomaly (Compva) criteria. MIT and specific agents were evaluated, and treatment effects were assessed through volumetry and mean signal intensity (MSI) on multiparametric longitudinal MRI.
View Article and Find Full Text PDFArticle Synopsis
- * The exact cause of peripartum cardiomyopathy is unclear, although factors like age, lifestyle, and genetics may play a role; recent theories suggest that an abnormal form of prolactin may contribute to the heart damage.
- * Ongoing research explores treatments like bromocriptine, a drug that inhibits prolactin, and highlights the importance of safe medication use during pregnancy and breastfeeding, particularly to protect both mothers and their babies.