Engaging Quad/Graphics employees in the improvement of their health and healthcare.

In an era when rising healthcare costs threaten the competitiveness of American businesses in an increasingly global marketplace, we describe Quad/Graphics on-site primary care (QuadMed) clinics tightly integrated with wellness, fitness, rehabilitation, and occupational medicine. We further describe the Lean You wellness program recently put in place to stem the rising burden of obesity. The Lean You program illustrates how an integrated employer and health provider system can become even more engaged in collaborative care with its employees.

Effects of renal dysfunction on the pharmacokinetics of loracarbef.

Loracarbef, the first carbacephem antibiotic to undergo clinical development, is excreted primarily unchanged in the urine (> 90%). Data analyzed from subjects with various degrees of renal dysfunction who were given single oral doses of loracarbef indicated a linear relationship between creatinine clearance (CLCR) and plasma clearance [CLP (L/hr) = 0.106.