Publications by authors named "L J Paterson"
Changes in the social mobility of men in Scotland between the late-19th and the late-twentieth century are examined using new individual-level data from nineteenth-century censuses, linking records of men aged 0-19 in 1871 to their records in 1901, and then comparing their patterns with the social mobility of men aged 30-49 in 1974 and in 2001 as recorded in social surveys at these dates. The extent of social mobility in the nineteenth century was large. In particular, the social origins of people in the highest classes-the salariat-were very varied, indicating a society that was more open than is sometimes supposed.
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- The research highlights a gap in addiction studies, which mostly focus on reward and impulsivity, while the withdrawal or negative affect stage—crucial for understanding relapse—has been less explored.
- Different substances show varying patterns of brain activity related to negative emotional processing, with regions like the amygdala, insula, anterior cingulate, and medial prefrontal cortex being implicated in substance dependence.
- Alcohol dependence tends to show blunted reactions to negative stimuli, cocaine dependence exhibits heightened responses, and opioid and cannabis dependence show distinct involvement of specific brain areas, indicating that emotional dysregulation in addiction is substance-specific.
Background: The Narrative Experiences Online (NEON) Intervention provides self-managed web-based access to mental health recovery narratives (n = 659). We evaluated effectiveness and cost-effectiveness in improving quality of life for adults resident in England with mental health problems and recent psychosis experience.
Methods: Prospectively registered pragmatic parallel-group randomised trial controlling for usual care, recruiting from statutory mental health services and through community engagement activities, with a 52-week primary endpoint (ISRCTN11152837).
Selective Deuteration and Tritiation of Pharmaceutically Relevant Sulfoximines.
Angew Chem Int Ed Engl
October 2024
Pharmaceutical-aligned research endeavors continue to diversify, including via the installation of new chemical functionality and non-classical bioisosteres within drug design. With this, an equally high demand emerges for the direct installation of isotopic substituents into these scaffolds within drug discovery programmes, as isotopologues are essential for the elucidation of the biological efficacy and metabolic fate of the active pharmaceutical ingredient (API). The sulfoximine functional group has recently become established as a high-value unit in this context; however, general and effective methods for the synthesis of deuterium (H, D) and tritium (H, T) labelled analogues have remained elusive.
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- The study explores how a sensory support intervention (SSI) program impacts quality of life in individuals with mild-to-moderate dementia who also have hearing and vision difficulties.
- Researchers conducted a randomized controlled trial across seven clinics in five European countries, evaluating the effectiveness of an 18-week program compared to standard care.
- The primary outcome measured was changes in health-related quality of life, using the Dementia Quality of Life Instrument (DEMQoL), with a total of 252 participants randomly assigned to either the SSI group or a control group receiving usual care.