Publications by authors named "L J Nicol"
Background: Drugs used to treat rheumatic disease are associated with pneumotoxicity (drug-induced lung disease), but little is known about associated risk factors.
Aim: To determine expert physician-perceived risk factors for developing pneumotoxicity in patients with rheumatologic conditions.
Methods: A modified international 3-tier Delphi exercise was performed.
Article Synopsis
- - Patients with chronic kidney disease (CKD) are at increased risk for heart-related issues, and medications like SGLT2 inhibitors (Dapagliflozin) and MRAs (Eplerenone) can help with cardiovascular problems, especially in diabetic cases.
- - A study tested the effects of Dapagliflozin and Eplerenone together on heart and kidney functions in rats with non-diabetic CKD, revealing that both drugs reduced kidney fibrosis and improved heart pressure and perfusion.
- - The combined treatment of Dapagliflozin and Eplerenone not only improved heart function but also showed a synergetic effect in reducing heart muscle damage compared to using each drug alone.
Article Synopsis
- MCT8 deficiency is a rare, X-linked disorder caused by mutations affecting thyroid hormone transport, leading to severe developmental delays and motor disabilities due to insufficient thyroid hormone in the brain.
- Diagnosis and treatment of MCT8 deficiency face major challenges, including a lack of awareness among healthcare professionals, resulting in misdiagnoses and delays, as well as complex symptoms that may not surface until months after birth.
- Multidisciplinary care is essential for optimal patient support, and while there are no specific treatments available yet, early diagnosis can help improve access to supportive care and developing interventions to enhance the quality of life for patients and their families.
Osteogenesis imperfecta (OI)is a rare genetically heterogeneous disorder caused by changes in the expression or processing of type I collagen. Clinical manifestations include bone fragility, decreased linear growth, and skeletal deformities that vary in severity. In typically growing children, skeletal maturation proceeds in a predictable pattern of changes in the size, shape, and mineralization on the hand and wrist bones that can be followed radiographically known at the bone age.
View Article and Find Full Text PDFBackground: The mineralocorticoid receptor plays a significant role in the development of chronic kidney disease (CKD) and associated cardiovascular complications. Classic steroidal mineralocorticoid receptor antagonists are a therapeutic option, but their use in the clinic is limited due to the associated risk of hyperkalemia in patients with CKD. Finerenone is a nonsteroidal mineralocorticoid receptor antagonist that has been recently investigated in 2 large phase III clinical trials (FIDELIO-DKD [Finerenone in Reducing Kidney Failure and Disease Progression in Diabetic Kidney Disease] and FIGARO-DKD [Finerenone in Reducing Cardiovascular Mortality and Morbidity in Diabetic Kidney Disease]), showing reductions in kidney and cardiovascular outcomes.
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