Publications by authors named "L J Morse"
Article Synopsis
- Spinal cord injury (SCI) below-level neuropathic pain is challenging to treat, but surgical lesions in the spinal cord’s dorsal root entry zone (DREZ) can target pain sources effectively.
- A study with eight patients showed significant improvement in pain relief after neuroelectrically guided DREZ microcoagulation surgery, with some experiencing long-term relief for over a year.
- Changes in brain connectivity were observed post-surgery, indicating that the procedure not only alleviated pain but also normalized brain function related to sensory and motor processing.
Neuropathic pain resulting from spinal cord injury (SCI) is a significant secondary health issue affecting around 60% of individuals with SCI. After SCI, activation of microglia, the immune cells within the central nervous system, leads to neuroinflammation by producing pro-inflammatory cytokines and affects neuropathic pain. This interplay between inflammation and pain contributes to the persistent and intense pain experienced by many individuals with SCI.
View Article and Find Full Text PDFBackground: Cancer-related cognitive impairment (CRCI) is reported by 45% of patients with cancer. Significant gaps in knowledge remain regarding the mechanisms that underlie CRCI.
Objectives: Using a data-driven approach, the study purpose was to evaluate for perturbed pathways associated with membership in the High versus the Low CRCI profiles.
Background: Centralized scheduling of nursing professionals is regarded as an effective strategy for optimizing workforce allocation and mitigating critical staffing shortages. The aim of this review is to (1) determine the effect of centralized scheduling on unit productivity (ie, overtime, contract labor, and floating), time savings for managers, and staff perceptions and retention and (2) discuss current approaches in the implementation of centralized scheduling in inpatient hospital settings.
Methods: This rapid review of the evidence follows methodological guidance from the Cochrane Rapid Reviews Methods Group.
Objectives: Shortness of breath is a common symptom in patients with cancer. However, the mechanisms that underlie this troublesome symptom are poorly understood. Therefore, this study aimed to determine the prevalence of and associated risk factors for shortness of breath in women prior to breast cancer surgery and identify associations between shortness of breath and polymorphisms for potassium channel genes.
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