Acute pancreatitis with panniculitis: a rare and striking clinical presentation.

Pancreatic panniculitis is a rare dermatological manifestation of pancreatic disorders, characterized by painful, erythematous nodules. We present the case of an 84-year-old woman with acute pancreatitis who developed erythematous-violaceous nodular lesions on her lower limbs. Histopathological examination revealed lobular panniculitis with fat necrosis and ghost adipocytes, confirming the diagnosis.

Association study of common variants with Hb F and Hb A levels in β-thalassaemia carriers of Portuguese ancestry.

Kruppel-like factor 1 (KLF1) is an essential erythroid-specific transcription factor. Several reports have shown that gene mutations are associated with increased levels of Hb F and Hb A. However, scarce population studies have analysed common variations.

Cat scratch colon and cecal barotrauma perforation during colonoscopy with CO2 insufflation.

Background: Cecal perforation from barotrauma is a rare complication of colonoscopy, even with the use of CO₂ insufflation, which is generally preferred over room air due to its rapid absorption and reduced patient discomfort.

Case Report: A 64-year-old woman with hypertension and dyslipidemia underwent a routine colonoscopy with CO₂ insufflation. Multiple diverticula were noted, and upon reaching the cecum, several parallel linear lesions with spontaneous bleeding, consistent with "cat scratch" colon, were observed.

A rare case of pancreatic pseudocyst-portal vein fistula in a patient with chronic pancreatitis.

A 60-year-old female with chronic pancreatitis and a history of splenectomy presented with epigastric pain, vomiting, and asthenia. Elevated pancreatic enzymes and CT imaging revealed a pseudocyst in the pancreatic head with suspected communication to the portal vein, confirmed by MR Cholangiopancreatography and endoscopic ultrasound (EUS). EUS-guided puncture revealed high amylase levels.

Unexpected diagnosis: IgG4-related sclerosing cholangitis with normal serum IgG4 levels - Unraveling diagnostic and therapeutic challenges.

Diagnosing IgG4-related sclerosing cholangitis (IgG4-SC) presents significant challenges, especially when serum IgG4 levels are normal and other organs are not involved. We report a case of a 51-year-old patient with typical symptoms of biliary obstruction, including jaundice and abdominal pain. Despite normal serum IgG4 levels, imaging suggested cholangiocarcinoma, leading to extensive surgical intervention.