Publications by authors named "L J M Mekenkamp"
Objective: To improve sustainability of a patient decision aid for systemic treatment of metastatic colorectal cancer, we evaluated real-world experiences and identified ways to optimize decision aid content and future implementation.
Methods: Semi-structured interviews with patients and medical oncologists addressed two main subjects: user experience and decision aid content. Content analysis was applied.
Article Synopsis
- The study highlights the slow implementation of cancer treatment guidelines in the Netherlands, specifically for pancreatic cancer, aiming to improve survival rates through better adherence to best practices.
- It involved a multicenter trial with 5887 patients, comparing enhanced treatment strategies against usual care from May 2018 to July 2020.
- Results showed that one-year survival rates were similar between both groups (24% vs 23%) and there wasn't a significant increase in adherence to the recommended treatment practices post-implementation.
Introduction: Physical activity (PA) is associated with higher quality of life and probably better prognosis among colorectal cancer (CRC) patients. This study focuses on determinants of PA among CRC patients from diagnosis until 5 yr postdiagnosis.
Methods: Sociodemographic and disease-related factors of participants of two large CRC cohort studies were combined.
Background: Biomarkers predicting treatment response may be used to stratify patients with pancreatic ductal adenocarcinoma (PDAC) for available therapies. The aim of this study was to evaluate the association of circulating cytokines with FOLFIRINOX response and with overall survival (OS).
Methods: Serum samples were collected before start and after the first cycle of FOLFIRINOX from patients with PDAC (=83) of all disease stages.
Regular physical activity (PA) is associated with improved overall survival (OS) in stage I-III colorectal cancer (CRC) patients. This association is less defined in patients with metastatic CRC (mCRC). We therefore conducted a study in mCRC patients participating in the Prospective Dutch Colorectal Cancer cohort.
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