Publications by authors named "L J Lauwerends"
Article Synopsis
- - Oesophageal cancer patients achieving a clinical complete response (CR) after neoadjuvant chemoradiotherapy (nCRT) may benefit from active surveillance; however, identifying true CRs is difficult due to a 40% regrowth rate in these patients.
- - The study examined pre-treatment and post-treatment tissue samples to analyze the expression of several tumor markers (CEA, EpCAM, VEGF-α, EGFR, c-MET) through immunohistochemistry, aiming to find markers for potential near-infrared fluorescence imaging.
- - Results showed high expression of EpCAM in adenocarcinomas and EGFR in squamous cell carcinomas, while neoadjuvant therapy did not alter the
Article Synopsis
- The study investigates the use of fluorescence imaging (FLI) to enhance the surgical identification of oral and laryngeal cancers (OSCC and LSCC) and papillary thyroid carcinoma (PTC), aiming to improve excision precision due to challenges in tumor delineation.
- Six potential tumor-targeting markers were evaluated through immunohistochemical staining in various cancer samples, with integrin αvβ6 and EGFR showing significant overexpression in OSCC and LSCC, indicating their effectiveness as FLI targets.
- The research suggests that although PTC shows lower expressions of these markers, the notable overexpression of VEGF-α and c-Met could also make them viable for improving
Near-infrared (NIR) fluorescence imaging using exogenous fluorescent agents provides whole-field images in real-time to assist the surgeon in the excision of a tumor. Although the method has high sensitivity, the specificity can sometimes be lower than expected. Raman spectroscopy can detect tumors with high specificity.
View Article and Find Full Text PDFA clear margin is an important prognostic factor for most solid tumours treated by surgery. Intraoperative fluorescence imaging using exogenous tumour-specific fluorescent agents has shown particular benefit in improving complete resection of tumour tissue. However, signal processing for fluorescence imaging is complex, and fluorescence signal intensity does not always perfectly correlate with tumour location.
View Article and Find Full Text PDFArticle Synopsis
- Colorectal cancer is a major global health issue, and near-infrared (NIR) fluorescence imaging is a promising new technique aimed at improving surgical precision and outcomes for patients undergoing surgery.
- A systematic literature review was performed to gather relevant trials related to fluorescence-guided surgery in colorectal cancer, identifying key applications like tumor imaging and lymph node assessment.
- Initial studies indicate that fluorescence-guided surgery can positively influence surgical management, but future research should prioritize patient outcomes like complication rates and survival.