Publications by authors named "L J Kappelle"
Article Synopsis
- Cerebral small vessel disease (SVD) can lead to various cerebrovascular issues, but research on sex differences in SVD is limited.
- This study analyzed data from over 20,000 patients with acute ischemic stroke to examine whether the presence and severity of cerebral microbleeds (CMB) and other SVD markers differ between males and females.
- Results showed that males had more frequent CMB while females had fewer lacunes but higher severe white matter hyperintensities, indicating distinct SVD characteristics based on sex.
Article Synopsis
- Cognitive impairment is prevalent in heart failure (HF) patients, and the study investigates sex differences in cognitive functioning linked to HF characteristics and brain injury.
- The research involved 162 HF patients who underwent neuropsychological assessments and brain MRI, revealing that women tend to perform better in global cognition and memory compared to men, despite differences in HF characteristics between sexes.
- Results showed that while some cognitive differences were associated with ischemic causes of HF, others, particularly in global cognition, persisted even after accounting for vascular brain injury factors.
Article Synopsis
- The study evaluated the PACAS risk model's ability to identify patients at high risk for severe asymptomatic carotid artery stenosis (ACAS) and predict future strokes and cardiovascular disease (CVD) risk.
- It involved 26,384 patients aged 45-80, finding that 6.3% had severe ACAS at baseline and that higher PACAS scores correlated with increased incidences of stroke and CVD over roughly 70,000 patient-years of follow-up.
- The PACAS model was confirmed to effectively discriminate and calibrate risk levels, indicating that patients with higher scores had a significantly higher prevalence of severe ACAS and related events during the follow-up period.